Leukocyte transfusions: function of transfused granulocytes from donors with chronic myelocytic leukemia.

The in vivo function of chronic myelocirculating granulocytes and severe transcytic leukemia (CML) leukocytes transfusion reactions, preformed leukoagglufused into infected patients with severe tinins were found. The poor granulocyte neutropenia was evaluated and the rerecoveries in these patients with antibody sults in four representative patients are could probably be explained by splenic reported. The intravascular survival, exsequestration of the transfused cells. travascular migration, and phagocytic These studies provide evidence supportcapacity of these cells appeared normal ing the use of CML leukocyte transin two patients without preformed leufusions in patients without preformed koagglutinins. In two other patients who leukocyte antibodies. had only small transient increments in